Statistical shrinkage models and variable selection via the Lasso; Longitudinal studies; Regressions with singular designs and age-period-cohort (APC) models; Statistical computing and small sample problems; Microarray gene expression data analysis and genetic association studies (SNP data analysis), haplotype analysis; Estimating DNA copy numbers and SNP genotype calling; Cancer incidence and mortalty trend, disparities across populations; Cancer screnning effect and testing; Economic and marketing research; Finance and stock market prediction; Sports data and game strategy research; Big data (high dimension and high complexity) modeling and applications to oil-gas industry.